Faculty Profile for Dr. Alexander Vladimir Kornienko

profile photo for Dr. Alexander Vladimir Kornienko
Dr. Alexander Vladimir Kornienko
Professor — Chemistry and Biochemistry
CHEM 319
phone: (512) 245-3632

Biography Section

Biography and Education

Postdoctoral Fellowship, Université de Montréal, Canada (Prof. Stephen Hanessian), 1999–2001
Ph.D. in Chemistry, Tufts University, Boston, USA (Prof. Marc d’Alarcao) 1994–1999
B.S in Chemical Engineering, Mendeleev University, Moscow, Russia, 1989–1994

Research Interests

Synthetic Organic Chemistry (total synthesis and methodology)
Chemical Biology (focus on cancer signaling and death pathways)
Medicinal Chemistry (rational drug design and library screening)
Natural Product Chemistry (isolation, structure elucidation and analogue synthesis)

Selected Scholarly/Creative Work

  • Reisenauer, K. N., Tao, Y. F., Das, P., Song, S. X., Svatek, H., D, P. S., … Taube, J. (2021). Epithelial-mesenchymal transition sensitizes breast cancer cells to cell death via the fungus-derived  sester-terpenoid ophiobolin A. Scientific Reports, 11(10652).
  • Wagh, S. B., Maslivetc, V., La Clair, J. J., & Kornienko, A. V. (2021). Lessons in organic fluorescent probe discovery. ChemBioChem, 22, 1–32.
  • Aksenov, A. V., Arutiunov, N. A., Kirilov, N. K., Aksenov, D. A., Grishin, I. Y., Aksenov, N. A., … Rubin, M. (2021). [3+2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor. Organic & Biomolecular Chemistry, 19, 7234.
  • Maslivetc, V., Laguera, B., Chandra, S., Dasari, R., Olivier, W., Smith, J., … Kornienko, A. V. (2021). Polygodial and Ophiobolin A Analogues for Covalent Crosslinking of Anticancer Targets. International Journal of Molecular Sciences, 22.
  • Ticli, V., Zhao, Z., Du, L., Kornienko, A. V., & Hudlicky, T. (2021). Synthesis and biological evaluation of 10-benzyloxy-Narciclasine. Tetrahedron, 101, 132505.

Selected Awards

  • Award / Honor Recipient: Holder of Denise M. Trauth Endowed Presidential Research Professorship, Texas State University. 2021 - Present
  • Award / Honor Recipient: Presidential Award for Scholarly/Creative Activities, President. January 31, 2016 - August 25, 2016

Selected Grants

  • Lewis, Karen A (Principal), Luxford, Cynthia J (Co-Principal), Vinciguerra, Brittany Marie (Co-Principal), Webre, Whitney Ann (Co-Principal), Holland, Cory Lee (Co-Principal), Betancourt, Tania (Supporting), Brittain, William J (Supporting), Hudnall, Todd W (Supporting), Irvin, Jennifer A (Supporting), Kerwin, Sean Michael (Supporting), Kornienko, Alexander Vladimir (Supporting), Peterson, Ryan Loren (Supporting), Rhodes, Christopher Peter (Supporting). REU Site: A Chemistry REU on Molecular Innovation and Exploration (CheMIE), National Science Foundation, Federal, $378188. (Submitted: August 25, 2021, Funded: April 15, 2022 - Present). Grant.
  • Du, Liqin (Principal), Kornienko, Alexander (Other), Houhgton, Peter (Other). Discovery of new differentiation agents for neuroblastoma therapy, National Institute of Health, NCI, R15, resubmissiom, Federal, $461574. (Funded: August 1, 2017 - July 31, 2020). Grant.
  • Kornienko, Alexander Vladimir (Co-Principal), Romo, Daniel (Principal). Pharmacophore-Directed Retrosynthesis Applied to Bioactive Natural Products Informing Mechanism of Action Studies, National Institutes of Health, Federal, $1422000. (Submitted: February 5, 2019, Funded: January 1, 2020 - December 31, 2024). Grant.
  • Kornienko, Alexander Vladimir (Principal), La Clair, James (Co-Principal). Tandem Discovery of Drug Leads and Targets via Paal-Knorr reaction, National Institutes of Health, Federal, $374000. (Funded: September 1, 2019 - August 31, 2021). Grant.
  • Kornienko, Alexander Vladimir (Principal), Sun, Dandan (Co-Principal). Acid-Sensitive Glioblastoma Prodrugs Derived from Ophiobolin A, National Institutes of Health, Federal, $461764. (Funded: February 1, 2019 - January 31, 2023). Grant.

Selected Service Activities

Editorial Review Board Member
Current Pharmaceutical Design
Editorial Review Board Member
Marine Drugs
August 28, 2019-Present
Departmental Safety Committee
Outstanding Master's Thesis Award Committee
Pre-Med/pre-Dent Review Panel