Faculty Profile for Dr. Alexander Vladimir Kornienko

profile photo for Dr. Alexander Vladimir Kornienko
Dr. Alexander Vladimir Kornienko
Professor — Chemistry and Biochemistry
CHEM 319
phone: (512) 245-3632

Biography Section

Biography and Education

Postdoctoral Fellowship, Université de Montréal, Canada (Prof. Stephen Hanessian), 1999–2001
Ph.D. in Chemistry, Tufts University, Boston, USA (Prof. Marc d’Alarcao) 1994–1999
B.S in Chemical Engineering, Mendeleev University, Moscow, Russia, 1989–1994

Research Interests

Synthetic Organic Chemistry (total synthesis and methodology)
Chemical Biology (focus on cancer signaling and death pathways)
Medicinal Chemistry (rational drug design and library screening)
Natural Product Chemistry (isolation, structure elucidation and analogue synthesis)

Selected Scholarly/Creative Work

  • Turner, D., Edwards, L., Kornienko, A. V., Frolova, L., & Rogelj, S. (2020). Synergistic action of substituted indole derivatives and clinically used antibiotics against drug-resistant bacteria. Future Microbiology, ahead of print.
  • van der Westhuyzen, A., Ingels, A., Rosière, R., Amighi, K., Oberer, L., Gustafson, K., … van Otterlo, W. (2020). Deciphering the chemical instability of sphaeropsidin A under physiological conditions – degradation studies and structural elucidation of the major metabolite. Organic & Biomolecular Chemistry, 18, 8147–8160.
  • Wagh, S., Maslivetc, V., La Clair, J., & Kornienko, A. V. (2020). A fluorescent target-guided Paal–Knorr reaction. RSC Advances, 10, 37035–37039.
  • Aksenov, N. A., Aksenov, A. V., Kirilov, N. K., Arutiunov, N. A., Aksenov, D. A., Maslivetc, V., … Kornienko, A. V. (2020). Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity. Organic & Biomolecular Chemistry, 18(34), 6651–6664. https://doi.org/https://doi.org/10.1039/D0OB01007C
  • Eyong, K. O., Ketsemen, H. L., Zhao, Z., Du, L., Ingels, A., Mathieu, V., … Romo, D. (2020). Anti-proliferative activity of naphthoquinones and indane carboxylic acids from lapachol against a panel of human cancer cell lines. Medicinal Chemistry Research, 29, 1058–1066.

Selected Awards

  • Award / Honor Recipient: Presidential Award for Scholarly/Creative Activities, President. January 31, 2016 - August 25, 2016

Selected Grants

  • Du, Liqin (Principal), Kornienko, Alexander (Other), Houhgton, Peter (Other). Discovery of new differentiation agents for neuroblastoma therapy, National Institute of Health, NCI, R15, resubmissiom, Federal, $461574. (Funded: August 1, 2017 - July 31, 2020). Grant.
  • Kornienko, Alexander Vladimir (Co-Principal), Romo, Daniel (Principal). Pharmacophore-Directed Retrosynthesis Applied to Bioactive Natural Products Informing Mechanism of Action Studies, National Institutes of Health, Federal, $1422000. (Submitted: February 5, 2019, Funded: January 1, 2020 - December 31, 2024). Grant.
  • Kornienko, Alexander Vladimir (Principal), La Clair, James (Co-Principal). Tandem Discovery of Drug Leads and Targets via Paal-Knorr reaction, National Institutes of Health, Federal, $374000. (Funded: September 1, 2019 - August 31, 2021). Grant.
  • Kornienko, Alexander Vladimir (Principal), Sun, Dandan (Co-Principal). Acid-Sensitive Glioblastoma Prodrugs Derived from Ophiobolin A, National Institutes of Health, Federal, $461764. (Funded: February 1, 2019 - January 31, 2022). Grant.
  • Kornienko, Alexander Vladimir, Hudnall, Todd (Principal). A Radical Approach to Photodynamic Therapy for the Non-invasive Treatment of Skin and Colorectal Cancers, Texas State University, $16000. (Submitted: October 2017, Funded: January 1, 2018 - December 31, 2018). Grant.

Selected Service Activities

Member
Faculty Search Committee
November 2020-Present
Editorial Review Board Member
Marine Drugs
August 28, 2019-Present
Member
Departmental Safety Committee
2018-Present
Member
Outstanding Master's Thesis Award Committee
2017-Present
Member
Pre-Med/pre-Dent Review Panel
2015-Present